MethylCC for RRBS data of Cord Blood

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weichen-cls • 0

@weichen-cls-23902

Last seen 4.3 years ago

Recently,I am working on a project about DNA methylation of Cord Blood and RRBS was applied.However, available version of methylCCis only suitable for Peripheral Blood since FlowSorted.Blood.450k but not FlowSorted.CordBlood.450k is used as reference. Is there any way to apply or modify methylCC for Cord Blood? Any suggestions would be appreciated!

MethylCC RRBS cord blood • 1.1k views

ADD COMMENT • link 4.3 years ago weichen-cls • 0

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Hi,

Unfortunately, I don't know of a way to do that at the moment. The software would need to be adapted to a different a different reference dataset. I plan on making some updates to this package in the Fall 2020 and could think more about how to make this package more flexible to alternative reference datasets. Thank you for the suggestion!

All the best, Stephanie

ADD REPLY • link 4.3 years ago Stephanie Hicks ▴ 80

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Also, I've opened up a GitHub issue to make sure to get back to this in the fall. Feel free to following along with the conversation there. https://github.com/stephaniehicks/methylCC/issues/4

ADD REPLY • link 4.3 years ago Stephanie Hicks ▴ 80

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