**120**wrote:

Hi,

I was trying to use DMRcate to find differentially methylated regions in illumina 450k methylation data. However, I need to account for covariates (e.g. age). I usually use the 'lm' function to find t-statistics and p-values associated with each CpG. However, with the DMRcate package, I can't see how I can incorporate the co-variates in the analysis.

Did I miss something?

thanks!

**80**• written 4.7 years ago by Brian Smith •

**120**