Question: ICU init failed: U_FILE_ACCESS_ERROR while loading library "VariantAnnotation"
gravatar for kmu004
3.6 years ago by
United States
kmu00440 wrote:


I am trying to install the "VariantAnnotation" library and load it. Although it installs without an issue it gives me an error while loading. Any help will be much appreciated.


.......package ‘VariantAnnotation’ successfully unpacked and MD5 sums checked

The downloaded binary packages are in

> library(VariantAnnotation)
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: ‘BiocGenerics’

The following objects are masked from ‘package:parallel’:

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ, clusterExport, clusterMap, parApply, parCapply, parLapply, parLapplyLB, parRapply, parSapply, parSapplyLB

The following object is masked from ‘package:stats’:


The following objects are masked from ‘package:base’:

    anyDuplicated, append,, as.vector, cbind, colnames,, duplicated, eval, evalq, Filter, Find, get, intersect, is.unsorted, lapply, Map, mapply, match,
    mget, order, paste, pmax,, pmin,, Position, rank, rbind, Reduce,, rownames, sapply, setdiff, sort, table, tapply, union, unique, unlist, unsplit

Loading required package: GenomeInfoDb
Loading required package: stats4
Loading required package: S4Vectors
Loading required package: IRanges
Loading required package: GenomicRanges
Loading required package: Rsamtools
Loading required package: XVector
Loading required package: Biostrings

Error in inDL(x, as.logical(local), as.logical(now), ...) :
  ICU init failed: U_FILE_ACCESS_ERROR
Error: package or namespace load failed for ‘VariantAnnotation’



R version 3.1.2 (2014-10-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)

[1] LC_COLLATE=English_United States.1252  LC_CTYPE=English_United States.1252    LC_MONETARY=English_United States.1252 LC_NUMERIC=C                         
[5] LC_TIME=English_United States.1252   

attached base packages:
[1] stats4    parallel  stats     graphics  grDevices utils     datasets  methods   base    

other attached packages:
[1] Rsamtools_1.18.2     Biostrings_2.34.1    XVector_0.6.0        GenomicRanges_1.18.4 GenomeInfoDb_1.2.4   IRanges_2.0.1        S4Vectors_0.4.0      BiocGenerics_0.12.1

loaded via a namespace (and not attached):
 [1] AnnotationDbi_1.28.1 base64enc_0.1-2      BBmisc_1.8           Biobase_2.26.0       biomaRt_2.22.0       bitops_1.0-6         brew_1.0-6           checkmate_1.5.1      codetools_0.2-9    
[10] DBI_0.3.1            digest_0.6.8         fail_1.2             foreach_1.4.2        iterators_1.0.7      RCurl_1.95-4.5       RSQLite_1.0.0        sendmailR_1.2-1      tools_3.1.2        
[19] XML_3.98-1.1         zlibbioc_1.12.0    

ADD COMMENTlink modified 3.6 years ago by Valerie Obenchain6.7k • written 3.6 years ago by kmu00440
Answer: ICU init failed: U_FILE_ACCESS_ERROR while loading library "VariantAnnotation"
gravatar for Valerie Obenchain
3.6 years ago by
United States
Valerie Obenchain6.7k wrote:

Hi Kavitha,

It looks you're working with packages from an old release (October 2014?). The current Bioconductor release is 3.1 (April 2015) and works with R 3.2.1. Can you update your R and Bioconductor packages? Help can be found here


ADD COMMENTlink written 3.6 years ago by Valerie Obenchain6.7k

Thanks, that worked :)

ADD REPLYlink written 3.6 years ago by kmu00440
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