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Comment: Highly DE genes but small count difference within conditions by Michael Love 42k

This last problem, I don't know how to help with, I think there's high variability here and not many degrees of freedom to overcome that

Answer: [DESeq2] Introduce a bias in DESeq2 by Michael Love 42k

This is often called an offset in statistical modeling. We have some support site posts about how to do this in DESeq2. Search for posts me…

Comment: Annotation for EPICv2 by shepherl 4.0k

Don't know if any of these are of use or if these are what ChAMP uses under the hood: [IlluminaHumanMethylationEPICv2anno.20a1.hg38](https…

Comment: minfi support of illumina Infinium methylationEPIC v2.0 by wl_xxz • 0

Hello James! Is there an annotation package for the latest EPICv2 A2 sub-version? If not, I am happy to make one by modifying the existing …

Comment: Highly DE genes but small count difference within conditions by bioshot.com • 0

Thanks for the suggestions. I simplified the model to *design=~genotype*. I tried both with and without *lfcshrinkage* and I am not finding…

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Trying to use enrichGO

Answer: dmpFinder for other objects

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