When I try to install the Bioconductor package org.Hs.eg.db (as well as certain other packages) on Mac OS X, I get the error message "ERROR: sub-architecture 'R' is not installed". For (e.g.) github packages, I can get rid of this error by saying:

install_github("package_name", args="--no-multiarch")

But how do I do this for Bioconductor packages?

Thanks in advance!

I think you mean install_github("package_name", INSTALL_opts="no-multiarch") ? The same syntax is supported by biocLite("org.Hs.eg.db", INSTALL_opts="no-multiarch"). Both install_github() and biocLite() are wrappers around install.packages(), and forward arguments there. `