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Comment: Package needs internet access
by
firestar
▴ 20
That worked! Thanks! I created the genome file locally and uploaded that. I didn't really think that BSgenome.Hsapiens.UCSC.hg38 was only u…
Comment: limma technical repeat correction
by
john
• 0
Hi @gordonsmyth, Thank you very much for your response. The normalization process involves multiple steps and they provide a normalised f…
Answer: Are unequal sample sizes in differential gene expression (DGE) analysis a proble
by
Gordon Smyth
51k
No, the imbalance in sample sizes doesn't effect the performance of any of the methods. It is not a problem. You should not be downsampling…
Comment: limma technical repeat correction
by
Gordon Smyth
51k
I have never analysed SomaScan data, so I cannot make any specific recommendations about how to analyse such data. I have however analysed …
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
by
Gordon Smyth
51k
voom() does not transform the data to be homoscedastic. Quite the opposite, it computes precision weights that reflect the mean-variance tr…
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Answer: Package needs internet access
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
Answer: Using voom-transformed counts for unsupervised analyses (PCA, Random Forest, Ela
Comment: Harmonizing Gene Annotations for Meta-Analysis of GSE68183 and GSE80178
Dotplot from enricher outputting very few genes
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