I have been trying to use the SearchSeq and searchAln function in package TFBSTools. But I always get errors even when running the demo R script provded in the Bioconductor.

> library(Biostrings)
> data(MA0003.2)
> data(MA0004.1)
> pwmList <- PWMatrixList(MA0003.2=toPWM(MA0003.2), MA0004.1=toPWM(MA0004.1),
+                         use.names=TRUE)
> subject <- DNAString("GAATTCTCTCTTGTTGTAGTCTCTTGACAAAATG")
> siteset <- searchSeq(pwm, subject, seqname="seq1", min.score="60%", strand="*")
Error in unsafe.update(object, ...) : 
  could not find function "unsafe.update"
> 
> sitesetList <- searchSeq(pwmList, subject, seqname="seq1",
+                          min.score="60%", strand="*")
Error in unsafe.update(object, ...) : 
  could not find function "unsafe.update"

I am wondering what is wrong in this case.

Does BiocInstaller::biocValid() indicate that some of your packages are out-of-date or too new?