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Answer: Deseq2 Design
by
James W. MacDonald
67k
Trying to use a conventional factor analysis, particularly if you are new, is not the way to go (I have been doing this for over 20 years n…
Answer: p value is 0, padj is 0
by
swbarnes2
★
1.4k
I think the default smallest value R will return is 1x10^-300. So I'd take a look at the counts, and see if it makes sense that the p-valu…
Comment: p value is 0, padj is 0
by
Michael Love
43k
```
> set.seed(1); t.test(rnorm(200,rep(c(0,80),each=100)) ~ rep(0:1,each=100))$p.value
[1] 0
```
Answer: Cannot install GO.db and org.Hs.eg.db
by
James W. MacDonald
67k
You might try tracing the namespace loading.
```
Sys.setenv("_R_TRACE_LOADNAMESPACE_"="2")
install("org.Hs.eg.db")
```
And see if th…
Answer: p value is 0, padj is 0
by
James W. MacDonald
67k
It is quite possible for a very small p-value to remain very small after multiplicity adjustment. I don't know the cutoff for `DESeq2` to r…
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