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Comment: How to use bootRanges to bootstrap small RNA loci (nullranges package) by Poonam • 0

I tried different block lengths first and considered 100000 to be ideal because of the almost similar inter-range distance. S1= bootRange…

Comment: How to use bootRanges to bootstrap small RNA loci (nullranges package) by Michael Love 41k

The segmentation and block length are key parameters. We recommend for example blocks of length ~500kb. It would help if you would post yo…

Answer: Handling multiple differential expression comparisons by Michael Love 41k

It's typical that results are presented with each group having its own FDR control. So presenting each comparison with the adjusted p-va…

Comment: Too many significant genes when integrating gtex and tcga by ATpoint ★ 4.1k

These two datasets are from completely different experiments / batches. It is utterly meaningless to compare them. I would suggest comparat…

Answer: fgsea significant result by ATpoint ★ 4.1k

Set a fixed seed before running this. Note that a FDR of 0.25 in fgsea is wildly and overly lenient. See https://support.bioconductor.o…

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Print Differentially Expressed Exons From Dexseq Results

Answer: Why does GSEA on edgeR results for randomized samples give highly significant p-

Answer: limma Intercept vs No-intercept models completely changing DMR results?

Answer: CombineArrays for EPIC and EPIC V2

Answer: Too many significant genes when integrating gtex and tcga

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