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StatisticalMethod
•
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1
vote
2
replies
286
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Detecting genomic signatures of drug resistance breast cancer in transcriptomic data
TransOmicsData
signatureSearchData
StatisticalMethod
written 4 months ago by
olusolaxx
• 0
0
votes
1
reply
442
views
Can we compare 3 different experimental conditions with DESeq2?
DESeq2
StatisticalMethod
updated 9 months ago by
swbarnes2
★ 1.4k • written 9 months ago by
Esteban
• 0
0
votes
0
replies
360
views
Job:
Post-Doc: Development of a new method to study the distribution of the effect sizes of QTL
StatisticalMethod
Evolution
QuantitativeTrailLocus
Genetics
JobPosting
10 months ago
pierre.devillemereuil
• 0
0
votes
3
replies
1.0k
views
Differences in differential analysis methods for RNA-Seq
DESeq2
StatisticalMethod
Proteomics
DifferentialExpression
RNASeq
updated 10 months ago by
ATpoint
★ 4.7k • written 10 months ago by
james.zhang20
• 0
2
votes
2
replies
2.8k
views
DESeq2 median of ratios normalization instead of VST or rlog for ordinations?
DESeq2
medianofratiostransformation
StatisticalMethod
Normalization
dispersion
14 months ago
Linton
• 0
1
vote
2
replies
973
views
How to perform longitudinal analysis using EdgeR
StatisticalMethod
FoldChange
edgeR
RNASeq
15 months ago
Sabiha
▴ 20
2
votes
2
replies
812
views
DESeq2: Comparison of single clinical sample to 4 normals using tumour cohort to infer dispersion of single sample
GeneExpression
DESeq2
RNASeqData
RNASeq
StatisticalMethod
16 months ago
Manthos
• 0
5
votes
2
replies
1.7k
views
DecideTest vs topTAGs in edgeR
RNAseq
StatisticalMethod
edgeR
updated 17 months ago by
Gordon Smyth
52k • written 17 months ago by
alvaroperona1
▴ 10
3
votes
2
replies
969
views
Does this RNAseq experiment require a repeated measures approach?
StatisticalMethod
RNASeqData
edgeR
DESeq2
updated 21 months ago by
Gordon Smyth
52k • written 21 months ago by
CDSPARKS
▴ 30
2
votes
3
replies
3.1k
views
deseq2 normalization and statistical method
normalization
deseq2
StatisticalMethod
updated 24 months ago by
ATpoint
★ 4.7k • written 2.0 years ago by
SH
▴ 10
2
votes
4
replies
1.0k
views
Model comparison in mean-dispersion trend in DESeq2
DESeq2
StatisticalMethod
2.1 years ago
Loïc
• 0
0
votes
2
replies
1.1k
views
Using Multi-Dimensional Scaling (MDS) to produce a vector in order to account for patient bias when constructing DGE lists from RNA-seq datasets in R?
PrincipalComponent
StatisticalMethod
edgeR
MultidimensionalScaling
Normalization
2.1 years ago
rcreswell01
• 0
1
vote
3
replies
1.4k
views
Limma-voom with inverse probability weights (similar to sample weights)
limma
limma-voom
StatisticalMethod
updated 2.1 years ago by
Gordon Smyth
52k • written 2.1 years ago by
jay
▴ 10
0
votes
1
reply
721
views
DESeq2 paired multifactor test
DESeq2
StatisticalMethod
updated 2.3 years ago by
Michael Love
43k • written 2.4 years ago by
ijvechetti
▴ 10
0
votes
0
replies
847
views
Job:
Academic position in Non-clinical Biostatistics
JobPosting
StatisticalMethod
2.4 years ago
Laurent Gatto
1.6k
1
vote
2
replies
1.4k
views
Limma adj.p.value the same for many different p.values
limmaGUI
limma
adj.p.value
StatisticalMethod
2.5 years ago
walkerrh95
• 0
0
votes
0
replies
1.2k
views
Job:
Postdoctoral research scientist in computational biology/statistical genetics/functional genomics at Columbia University, USA
Alzheimer's
StatisticalMethod
Genetics
molecularQTL
FunctionalGenomics
2.5 years ago
gaow
• 0
0
votes
0
replies
743
views
Should I adjust p value for multi-levels (groups) and multi-variables?
StatisticalMethod
3.0 years ago
dong
▴ 10
2
votes
3
replies
5.3k
views
Differential gene expression and (adjusted) p-values
edgeR
StatisticalMethod
updated 2.9 years ago by
ruez.richard
• 0 • written 3.1 years ago by
tmms
• 0
6
votes
4
replies
1.3k
views
Limma prametrization
limm
MathematicalBiology
limmaGUI
StatisticalMethod
3.2 years ago
Giovanni
• 0
2
votes
7
replies
1.9k
views
EdgeR, tumor normal pair, no replicatie but multiple patients, to focus on individual patients not combined
edgeR
StatisticalMethod
3.5 years ago
Field -Ye
• 0
0
votes
2
replies
1.9k
views
To retrieve the transcript from gff file with the longest isoform
FunctionalAnnotation
StatisticalMethod
3.8 years ago • updated 3.7 years ago
Aneesha
• 0
0
votes
1
reply
989
views
DESeq2 Design matrix
StatisticalMethod
DESeq2
updated 3.8 years ago by
Michael Love
43k • written 3.9 years ago by
Saif
• 0
6
votes
6
replies
2.1k
views
limma:arrayWeights() and the "prior.n" parameter for biological replicates? (PROTEOMICS)
Proteomics
limma
StatisticalMethod
updated 4.0 years ago by
Gordon Smyth
52k • written 4.0 years ago by
Steve
▴ 10
1
vote
3
replies
1.4k
views
How to assign random effect factor in DESeq2 desing?
StatisticalMethod
DESeq2
phyloseq
updated 4.1 years ago by
Michael Love
43k • written 4.1 years ago by
zardbid
• 0
0
votes
0
replies
1.5k
views
Why is `scale-free topology` estimated as -sign(slope) * (R^2) in WGCNA?
Network
StatisticalMethod
WGCNA
ExpressionData
4.2 years ago
jol.espinoz
▴ 40
0
votes
2
replies
918
views
p adjusted value not available
StatisticalMethod
DESeq2
updated 4.3 years ago by
Kevin Blighe
★ 4.0k • written 4.3 years ago by
marie
• 0
27 results • Page
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Replies
Comment: DiffBind custom normalization factor
by
Abbie
• 0
Hello! Thanks so much for adding dba.normalize and all the documentation in the manual! I'm hoping I can ask a follow-up question here. I…
Answer: CpGs with genomic positions greater than the chromosome size in EPICv2?
by
James W. MacDonald
68k
All of the annotation packages provided by Bioconductor are simply repackaging of existing data from one or more sources. In this case, the…
Comment: Using TPM from tximport of Salmon output for singscore
by
Kent
• 0
Thank you for the suggestions Michael. Would you say that after filtering out the low count genes, `rlog(counts, blind = T)` is doing the s…
Comment: Using TPM from tximport of Salmon output for singscore
by
Michael Love
43k
For clustering generally we recommend `vst()` see the workflow for example. For working with individual samples, I can see how a scaling/t…
Comment: DESeq2 model - How to test case/control time course model when taking account wi
by
Michael Love
43k
I'd recommend working with a local statistician or someone familiar with linear models in R. I have to reserve my time on the support site …
Votes
clusterProfiler-GO enrichment Error
A: Machine learning in R book
Data preparation and Machine learning on time course RNAseq data
Data preparation and Machine learning on time course RNAseq data
Answer: Use of org.Rn.eg.db with GRCr8 reference genome
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Dario Strbenac
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Gordon Smyth
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