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Perhaps PCA loadings offer a more comprehensive perspective. Now, thinking back, I recall struggling with a similar data reduction dilemma …
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Depends on what you mean by input. If you mean to ask if you use `readBam` to generate something to use as an argument to `read_bam_insert_…
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There is an example in the help page for `forgeBSgenomePkgFromTwobitFile`. Have you tried emulating that?
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What you describe sounds a good approach to me.
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