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10
votes
14
replies
15k
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how DESeq calculates p-value ?
deseq
differential gene expression
statistics
p-value
updated 4.2 years ago by
Kai_Qi
▴ 20 • written 9.3 years ago by
Giard
▴ 30
28
votes
7
replies
13k
views
Effect of lfcThreshold on p-value in DESeq2
deseq2
rnaseq
statistics
updated 19 months ago by
camillab.
▴ 10 • written 7.6 years ago by
Russ Fraser
▴ 40
19
votes
4
replies
9.3k
views
Confidence intervals on edgeR logFC
edgeR
statistics
confidence interval
updated 9.1 years ago by
nwvidal
• 0 • written 10.7 years ago by
ri.lars
▴ 40
2
votes
2
replies
9.1k
views
edgeR: How is FDR calculated for logFC? (False Discovery Rate)
edgeR
bioconductor
fdr
statistics
differential gene expression
8.5 years ago • updated 8.4 years ago
jol.espinoz
▴ 40
8
votes
8
replies
8.5k
views
Voom transformation from counts and normalization to negative values
rnaseq
voom
limma
tcga
statistics
updated 6.7 years ago by
Ryan C. Thompson
★ 7.9k • written 6.7 years ago by
Beginner
▴ 60
0
votes
4
replies
6.1k
views
10 multiple comparisons in DESeq2
deseq2
rnaseq
statistics
updated 8.9 years ago by
Michael Love
43k • written 8.9 years ago by
kissmatee
• 0
2
votes
2
replies
4.2k
views
How adjusted p-values are calculated in limma
limma
r
transcriptomics
FDR
statistics
updated 5.6 years ago by
Gordon Smyth
52k • written 5.6 years ago by
Wuschel
▴ 10
8
votes
3
replies
3.9k
views
Differing topTable() results with Limma with and without specifying coefficient
limma
microarray
statistics
updated 9.1 years ago by
Gordon Smyth
52k • written 9.1 years ago by
krr
• 0
1
vote
6
replies
3.5k
views
DESeq2 unbalanced sample size
deseq2
bioconductor
bioinformatics
statistics
updated 2.2 years ago by
Michael Love
43k • written 6.4 years ago by
casikecola
• 0
0
votes
4
replies
3.4k
views
XCMS for targeted metabolomic/lipidomics/proteomics
xcms
metabolomics
lipidomics
statistics
9.4 years ago
Titan
• 0
1
vote
2
replies
3.1k
views
the statistical test that DESeq2 use
deseq2
statistics
updated 8.3 years ago by
Ryan C. Thompson
★ 7.9k • written 8.3 years ago by
elhamdallalbashi
• 0
1
vote
1
reply
3.0k
views
FPKM t-test vs DEseq2
DESeq2
statistics
rna-seq
updated 2.1 years ago by
ATpoint
★ 4.8k • written 2.1 years ago by
SH
▴ 10
3
votes
0
replies
2.7k
views
Job:
Postdoctoral Scientist, Statistical Bioinformatics and Proteomics, WEHI Australia
job
proteomics
Job
statistics
5.5 years ago • updated 5.4 years ago
Gordon Smyth
52k
1
vote
2
replies
2.3k
views
how to perform pre ranked GSEA in R?
r
microarray
statistics
GSEA
updated 8.2 years ago by
predeus
• 0 • written 10.2 years ago by
Nemo
▴ 80
1
vote
0
replies
2.3k
views
Job:
Postdoctoral Research Fellow in Bioinformatics - Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Mainz, Germany
bioinformatician job
rnaseq
statistics
systemsbiology
Job
10.0 years ago
Federico Marini
▴ 180
0
votes
0
replies
2.2k
views
Job:
Full position as Statistician at ETH Zurich in Personalized Medicine Consultancy/Data Analysis
statistics
consultancy
personalized medicine
Job
10.6 years ago
Daniel Stekhoven
▴ 10
0
votes
0
replies
2.2k
views
Job:
Postdoc and PhD student in Bioinformatics/Biostatistics
genomics
NGS
R
genetics
statistics
6.9 years ago • updated 4.5 years ago
Luo Weijun
★ 1.6k
0
votes
0
replies
2.1k
views
News:
Workshop on Statistical Challenges in Single-Cell Biology, April 30 to May 5, 2017, at Villa Monte Verita, Ascona
workshop
statistics
single-cell
News
8.7 years ago
Wolfgang Huber
★ 13k
0
votes
0
replies
2.1k
views
Job:
Bioinformatics Programmer (Statistician) at University of California at San Francisco
R
bioinformatician job
Perl
Python
statistics
Job
9.1 years ago • updated 8.8 years ago
clif.duhn
• 0
1
vote
0
replies
2.0k
views
News:
Workshop Statistical Methods for Post Genomic Data in Munich, February 12-13, 2015
statistics
workshop
news
News
10.6 years ago
gagneur
▴ 10
0
votes
3
replies
2.0k
views
Reading large file (15GB) in R
R
Rstudio
Bioconducter
statistics
updated 3.2 years ago by
Sean Davis
21k • written 3.3 years ago by
Jitendra
▴ 10
3
votes
3
replies
1.9k
views
Using alternative LFC shrinkage methods for computing p-values in DESeq2
deseq2
apeglm
statistics
updated 6.0 years ago by
Michael Love
43k • written 6.0 years ago by
zefrieira
• 0
0
votes
3
replies
1.9k
views
batch effect in EPIC array data
statistics
Epigenetics
R
updated 2.2 years ago by
Lluís Revilla Sancho
▴ 760 • written 2.2 years ago by
Jitendra
▴ 10
2
votes
3
replies
1.9k
views
RNAseq outlier is a critical sample
rnaseq
outlier
statistics
batch effect
updated 9.0 years ago by
Gordon Smyth
52k • written 9.0 years ago by
grastalt27
• 0
0
votes
0
replies
1.8k
views
Job:
Research Scientist in Biostatistics/Bioinformatics
statistics
genetics
genomics
R
Job
8.3 years ago • updated 8.1 years ago
Luo Weijun
★ 1.6k
0
votes
0
replies
1.8k
views
Job:
Computational Biologist (Genome Statistical Analyst) position in CRUK Manchester Institute, UK
job
bioinformatics
ngs
genomics
statistics
Job
9.2 years ago
Hui Sun Leong
▴ 10
1
vote
0
replies
1.8k
views
Job:
PhD Positions in Computational Cancer Research
computational biology
image analysis
cancer genomics
statistics
Job
8.5 years ago
Bernd Fischer
▴ 550
0
votes
6
replies
1.8k
views
regression analysis for epic array methylation data using limma
limma
Epigenetics
STATISTICS
R
3.0 years ago
Jitendra
▴ 10
0
votes
0
replies
1.7k
views
Job:
Come apply for our Epidemiologist, AncestryHealth role
genomics
genetics
design
statistics
scientist
Job
9.9 years ago
careers
• 0
3
votes
5
replies
1.7k
views
P adjusted values in Deseq2
DESeq2
Statistics
written 4.4 years ago by
Jesus
• 0
1
vote
4
replies
1.6k
views
Do the gene set statistics of the ROAST paper correspond to those implemented in the .roastEffects R function?
limma
roast
statistics
source code
gene set testing
6.8 years ago • updated 6.7 years ago
Andrea Carenzo
• 0
0
votes
2
replies
1.6k
views
Compute test-score statistical significance using control-scores from shuffled population
statistics
hypotheses
R
9.2 years ago
Bade
▴ 310
1
vote
2
replies
1.5k
views
Re-calculation of Padj (P adjusted value)
statistics
Benjamini–Hochberg procedure
deseq2
updated 4.6 years ago by
Michael Love
43k • written 4.6 years ago by
Matan G.
▴ 60
0
votes
0
replies
1.5k
views
Job:
Postdoc and PhD student in Bioinformatics/Biostatistics
NGS
R
statistics
genomics
big data
Job
6.3 years ago • updated 5.5 years ago
Luo Weijun
★ 1.6k
0
votes
0
replies
1.5k
views
Job:
Postdoc in Biostatistics/Bioinformatics at UNC Charlotte, NC, USA
genetics/genomics
omics data
statistics
development
R
Job
8.8 years ago • updated 8.7 years ago
Luo Weijun
★ 1.6k
2
votes
4
replies
1.5k
views
Removing batch effect on edgeR when interactons are looked at
rnaseq
edger
statistics
model matrix
updated 7.6 years ago by
Steve Lianoglou
★ 13k • written 7.6 years ago by
David R
▴ 90
0
votes
0
replies
1.5k
views
DSS DMLTest Prior Estimate of theta dispersion
DSS
dmltest
bayesian
statistics
methylation
7.1 years ago
floriandeckert
▴ 30
0
votes
0
replies
1.5k
views
Job:
Bioinformaticist, Research Programmer
R
genomics
statistics
Job
8.2 years ago
radel
• 0
0
votes
0
replies
1.5k
views
Two questions about pathifier package
pathways
statistics
microarray
7.4 years ago
arronar
• 0
1
vote
0
replies
1.5k
views
Job:
Statistical Research Associate
biostatistics
statistics
sas
git
assay
Job
7.1 years ago
Fred Hutch (Recruiting)
▴ 40
0
votes
0
replies
1.4k
views
Job:
Seeking computational biologists with expertise in RNA-Seq and/or statistics at Immuneering Corporation, Cambridge MA and New York NY
rna-seq
CNS
Neurodegeneration
statistics
computational biology
Job
8.6 years ago
mmartin
▴ 20
0
votes
0
replies
1.4k
views
Assigning stats to differential peak locations relative to TSS
chipseeker
chipseq
statistics
7.6 years ago
rbronste
▴ 60
0
votes
2
replies
1.4k
views
comparing two GOstats result lists
gostats
statistics
updated 7.0 years ago by
James W. MacDonald
68k • written 7.0 years ago by
sven.schenk
▴ 30
0
votes
0
replies
1.4k
views
News:
SCANGEN: Single-cell cancer genomics workshop at ISMB 2018
single cell
cancer genomics
statistics
News
7.2 years ago
kieranrcampbell
▴ 50
0
votes
0
replies
1.4k
views
Job:
Proteomics Bioinformatician
JobPosting
Proteomics
Statistics
Job
4.4 years ago
Laura
• 0
0
votes
5
replies
1.4k
views
Comparing sets of differentially expressed genes
deseq2
rnaseq
statistics
9.6 years ago
sunkid
• 0
0
votes
0
replies
1.4k
views
Job:
Biostatistics/Bioinformatics Research Scientist at UNC Charlotte
singlecellRNA-Seq
pathview
statistics
R
4.2 years ago • updated 4.0 years ago
Luo Weijun
★ 1.6k
0
votes
2
replies
1.4k
views
News:
Ascona Workshop “Biological systems: from first principles to data-driven modelling and back” 27. 3. - 1. 4. 2022
theory
modeling
statistics
ascona
Workshop
3.6 years ago • updated 2.3 years ago
Wolfgang Huber
★ 13k
2
votes
2
replies
1.4k
views
limma for gene expression analysis with big and unbalanced sample size
limma
microarray
statistics
updated 12 months ago by
XW
• 0 • written 9.0 years ago by
tati6406
• 0
0
votes
0
replies
1.3k
views
Proteomics data analysis with DEP no replicates
DEP
Proteomics
Statistics
limma
5.8 years ago
tatabox
• 0
50 results • Page
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Comment: Memory issue while using "quickcluster" and "computeSumFactors" functions on sin
by
ATpoint
★ 4.8k
What is lac cells? You mean 7000-9000 cells? Please check first that the function runs OOM even without any of these multicore options set.…
Comment: parameters of filterByExpr
by
caroline.zanchi
▴ 10
It worked, I think I finally understand and accept that fact. Sorry and thank you again !
Comment: parameters of filterByExpr
by
Gordon Smyth
52k
You seem to be coming back to the same fixed (but incorrect) idea of what filterByExpr() should be doing. I have tried to explain that filt…
Answer: edgeR in DMR mode - replicates give batch effect - how to build design matrix wi
by
Gordon Smyth
52k
modelMatrixMeth() works correctly. The second replicate factor has not been lost. Please do not make ad hoc manual modifications to the de…
Comment: Adding gene names as row annotations to an RNAseq heatmap made with ComplexHeatm
by
James W. MacDonald
68k
Probably not. Any given gene may be appended with many different GO terms, so you would end up with something that is not very useful. ``…
Votes
Answer: parameters of filterByExpr
Comment: Heatmap of rnaseq data with z-score scale
Answer: LogFC values in edgeR - w/wo intercept
How to formulate 2 factor nested design in DESeq2
Answer: Adding gene names as row annotations to an RNAseq heatmap made with ComplexHeatm
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